For pregnant women who have a history of preterm birth, AmeriHealth covers two 
injectable drugs to reduce the risk of preterm birth:
 
- the preservative-free compound 17-alpha-hydroxyprogesterone caproate 
(17P)
- Makena®, which is approved by the U.S. Food and Drug 
Administration
Both drugs use the same active pharmaceutical ingredients and are available 
through the AmeriHealth Direct Ship Injectables Program, but Makena contains 
preservatives as a result of the manufacturing process. Providers are 
encouraged to select the drug that is appropriate for each individual patient, 
given her unique circumstances.
For more information about 17P and Makena, visit the AmeriHealth 
Medical Policy portal to review 
Medical Policy #08.01.00c: Hydroxyprogesterone Caproate Injection as a 
Technique to Reduce the Risk of Preterm Birth in High-Risk Pregnancies.